Abstract: SAMI2 (Sami is Another Model of the Ionosphere) is a theoretical ionosphere model developed by the U.S. Navy Research Lab (NRL) which has been widely used in ionospheric research. In this paper, the total electron content ( TEC ) of ionosphere from SAMI2 and GPS at different latitudes in East Asia sector with different solar activities have been selected as a comparison to estimate the accuracy of SAMI2. The results show that the SAMI2 TEC  have same diurnal, seasonal and solar activity variations with GPS TEC . SAMI2 coincides better with the observation data in morning than in the afternoon. In the seasonal distribution, SAMI2 TEC  has small deviation from the observation in winter. The correlation coefficient between SAMI2 TEC  and GPS TEC  is above 0.87 at each station. In most cases, the SAMI2 overestimate the ionosphere TEC.