Abstract: The 12-year coordinate sequence of 12 GPS stations is studied. The estimation criterion of KIC noise model is used to estimate the four combined noise characteristics, and the influence of slow slip phenomenon on GPS station coordinate time series is discussed. The results show that ETS causes the change of GPS station coordinate sequence model, and the ratios of E, N direction component noise model and U component model are quite different, which may cause erroneous estimation of noise model; the speed of the station and its uncertainty after slow slip are larger than before slow slip; and obvious for the U component. The station at special geographical location can carry out the marking research to minimize the adverse effects caused by the earthquake movement, and study the crustal movement, whih can provide valuable reference materials.