Abstract: Digital Orthophoto Map (DOM) uses digital differential rectification method to eliminate projection error caused by tilted camera and topographic relief, but it can produce double projection phenomenon. True digital orthophoto map (TDOM) can effectively solve the double projection phenomenon of DOM. A method for making TDOM based on the real three-dimensional(3D) model of the Unmanned Aerial Vehicle(UAV) image is proposed. First, the aerial photogrammetry image acquired by UAV mounting five-lens camera and 3D model of real scene is generated. Then the top contour boundary line of the building is collected and its 3D volume model is constructed. Finally, TDOM is generated by occlusion detection and compensation based on 3D model of building top contour boundary line. The UAV image of Yunnan Normal University in Chenggong as experimental data is used as experimental data to verify the proposed method, and the experiments show that the method can be used to generate high quality TDOM.